Detailed view for OVOC1127

Basic information

TDR Targets ID: 987962
Onchocerca volvulus,
Source Database / ID:  Wormbase Parasite  

pI: 9.8529 | Length (AA): 372 | MW (Da): 42378 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 5

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00651  
PF01363  
PF12796  

Gene Ontology

Mouse over links to read term descriptions.
GO:0046872   metal ion binding  
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 13 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
47 148 3fkc (A) 13 115 17.00 0 0.96 0.326308 -0.25
135 255 2d2s (A) 552 704 31.00 0.84 0.13 0.133002 0.89
356 467 3aaa (C) 4 113 18.00 0 0.99 0.417357 -0.82
409 1014 4rlv (A) 2051 2565 30.00 0 1 0.594916 1.23
465 762 4g8k (A) 34 296 28.00 0.000000041 1 0.378183 0.71
682 885 2fo1 (E) 1081 1286 27.00 0.000082 1 0.424115 0.2
694 880 1k1a (A) 155 341 30.00 0.000000011 1 0.643731 -1.05
697 875 2rfm (A) 26 166 36.00 0.000097 0.81 0.257491 0.55
801 926 5eil (A) 0 122 39.00 0 1 0.690527 -1.27
835 897 1ycs (B) 355 417 40.00 0.000049 1 0.582514 -0.36
874 911 1n11 (A) 405 442 47.00 0 0.9 0.562389 0.05
911 1044 4gmr (A) 42 168 18.00 0.000056 0.31 0.322167 -0.7
1039 1100 1vfy (A) 170 231 42.00 0 0.94 0.498109 0.45

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132267)

Species Accession Gene Product
Brugia malayi Bm1_48190   FYVE zinc finger family protein
Caenorhabditis elegans CELE_F22G12.4   Protein F22G12.4, isoform A
Drosophila melanogaster Dmel_CG41099   CG41099 gene product from transcript CG41099-RD
Homo sapiens ENSG00000185722   ankyrin repeat and FYVE domain containing 1
Loa Loa (eye worm) LOAG_07766   hypothetical protein
Loa Loa (eye worm) LOAG_13465   FYVE zinc finger family protein
Loa Loa (eye worm) LOAG_09760   hypothetical protein
Mus musculus ENSMUSG00000020790   ankyrin repeat and FYVE domain containing 1
Onchocerca volvulus OVOC1127  
Schistosoma japonicum Sjp_0080620   Ankyrin repeat and FYVE domain-containing protein 1, putative
Schistosoma japonicum Sjp_0043620   Ankyrin repeat and FYVE domain-containing protein 1, putative
Schistosoma mansoni Smp_132450.2   ankyrin repeat and fyve domain containing
Schistosoma mansoni Smp_132450.1   ankyrin repeat and fyve domain containing
Schmidtea mediterranea mk4.010114.00  
Schmidtea mediterranea mk4.009042.00  
Schmidtea mediterranea mk4.009042.02  
Schmidtea mediterranea mk4.001171.07  
Schmidtea mediterranea mk4.011620.00  

Essentiality

OVOC1127 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F22G12.4 Caenorhabditis elegans embryonic lethal wormbase
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier OVOC1127 (Onchocerca volvulus),
Title for this comment
Comment